| 1 | Run It!Chris Brown | 1 | Chart history → |
| 2 | Gold DiggerKanye West Featuring Jamie Foxx | 2 | Chart history → |
| 3 | My HumpsThe Black Eyed Peas | 3 | Chart history → |
| 4 | Laffy TaffyD4L | 6 | Chart history → |
| 5 | Soul SurvivorYoung Jeezy Featuring Akon | 4 | Chart history → |
| 6 | PhotographNickelback | 5 | Chart history → |
| 7 | Hung UpMadonna | 7 | Listen & explore → |
| 8 | StickwituThe Pussycat Dolls | 10 | Chart history → |
| 9 | We Be Burnin'Sean Paul | 8 | Chart history → |
| 10 | Because Of YouKelly Clarkson | 9 | Chart history → |
| 11 | There It Go! (The Whistle Song)Juelz Santana | 19 | Chart history → |
| 12 | Don't Forget About UsMariah Carey | 11 | Chart history → |
| 13 | I'm SprungT-Pain | 12 | Chart history → |
| 14 | Stay FlyThree 6 Mafia Featuring Young Buck & Eightball & MJG | 13 | Chart history → |
| 15 | I Think They Like MeDem Franchize Boyz Featuring Jermaine Dupri, Da Brat & Bow Wow | 15 | Chart history → |
| 16 | One WishRay J | 16 | Chart history → |
| 17 | Sugar, We're Goin' DownFall Out Boy | 14 | Chart history → |
| 18 | Here We GoTrina Featuring Kelly Rowland | 17 | Chart history → |
| 19 | GrillzNelly Featuring Paul Wall, Ali & Gipp | 52 | Chart history → |
| 20 | Shake It OffMariah Carey | 18 | Chart history → |
| 21 | LuxuriousGwen Stefani | 24 | Chart history → |
| 22 | Wake Me Up When September EndsGreen Day | 21 | Chart history → |
| 23 | Window Shopper50 Cent | 20 | Chart history → |
| 24 | Girl ToniteTwista Featuring Trey Songz | 22 | Chart history → |
| 25 | When I'm GoneEminem | 69 | Chart history → |
| 26 | Dance, DanceFall Out Boy | 29 | Chart history → |
| 27 | Check On ItBeyonce Featuring Slim Thug | 34 | Chart history → |
| 28 | Like YouBow Wow Featuring Ciara | 23 | Chart history → |
| 29 | You And MeLifehouse | 25 | Chart history → |
| 30 | Dirty Little SecretThe All-American Rejects | 39 | Chart history → |
| 31 | Beverly HillsWeezer | 28 | Chart history → |
| 32 | Feel Good IncGorillaz | 27 | Chart history → |
| 33 | Don't ChaThe Pussycat Dolls Featuring Busta Rhymes | 30 | Chart history → |
| 34 | Come A Little CloserDierks Bentley | 31 | Chart history → |
| 35 | Heard 'Em SayKanye West Featuring Adam Levine | 38 | Chart history → |
| 36 | Your BodyPretty Ricky | 26 | Chart history → |
| 37 | Tequila Makes Her Clothes Fall OffJoe Nichols | 32 | Chart history → |
| 38 | I Should Have CheatedKeyshia Cole | 35 | Chart history → |
| 39 | UnbreakableAlicia Keys | 36 | Chart history → |
| 40 | We Belong TogetherMariah Carey | 33 | Chart history → |
| 41 | Who You'd Be TodayKenny Chesney | 37 | Chart history → |
| 42 | Behind These Hazel EyesKelly Clarkson | 40 | Chart history → |
| 43 | Seasons Of LoveCast Of Rent | 62 | Chart history → |
| 44 | Pon de ReplayRihanna | 41 | Chart history → |
| 45 | Jesus, Take The WheelCarrie Underwood | 42 | Chart history → |
| 46 | If It's Lovin' That You WantRihanna | 51 | Chart history → |
| 47 | Honky Tonk BadonkadonkTrace Adkins | 50 | Chart history → |
| 48 | Like We Never Loved At AllFaith Hill | 45 | Chart history → |
| 49 | Must Be Doin' Somethin' RightBilly Currington | 54 | Chart history → |
| 50 | Be Without YouMary J. Blige | 60 | Chart history → |
| 51 | Turn It UpChamillionaire Featuring Lil' Flip | 70 | Chart history → |
| 52 | ShakeYing Yang Twins Featuring Pitbull | 48 | Chart history → |
| 53 | Better LifeKeith Urban | 46 | Chart history → |
| 54 | More Than WordsFrankie J | 56 | Chart history → |
| 55 | Best I Ever HadGary Allan | 55 | Chart history → |
| 56 | BoyfriendAshlee Simpson | 47 | Chart history → |
| 57 | Kryptonite (I'm On It)Purple Ribbon All-Stars | 75 | Chart history → |
| 58 | Belly Dancer (Bananza)Akon | 57 | Chart history → |
| 59 | Big Blue NoteToby Keith | 65 | Chart history → |
| 60 | BoondocksLittle Big Town | 64 | Listen & explore → |
| 61 | HypnotizeSystem Of A Down | 89 | Chart history → |
| 62 | Don't BotherShakira | 79 | Chart history → |
| 63 | Don't LieThe Black Eyed Peas | 61 | Chart history → |
| 64 | She Let Herself GoGeorge Strait | 71 | Chart history → |
| 65 | Better DaysGoo Goo Dolls | 68 | Chart history → |
| 66 | Lighters UpLil' Kim | 59 | Chart history → |
| 67 | You're BeautifulJames Blunt | 63 | Chart history → |
| 68 | Skin (Sarabeth)Rascal Flatts | 53 | Chart history → |
| 69 | Good Ride CowboyGarth Brooks | 66 | Chart history → |
| 70 | Can I Have It Like ThatPharrell Featuring Gwen Stefani | 67 | Chart history → |
| 71 | Just The GirlThe Click Five | 83 | Chart history → |
| 72 | FiremanLil Wayne | 85 | Chart history → |
| 73 | Miss Me BabyChris Cagle | 80 | Chart history → |
| 74 | DOAFoo Fighters | 76 | Chart history → |
| 75 | Comin' To Your CityBig & Rich | 72 | Chart history → |
| 76 | Soul Meets BodyDeath Cab For Cutie | 77 | Chart history → |
| 77 | UnwrittenNatasha Bedingfield | — | Chart history → |
| 78 | Something To Be Proud OfMontgomery Gentry | 74 | Chart history → |
| 79 | So SickNe-Yo | — | Chart history → |
| 80 | Bat CountryAvenged Sevenfold | 82 | Chart history → |
| 81 | When I Get Where I'm GoingBrad Paisley Featuring Dolly Parton | 81 | Chart history → |
| 82 | I'm Feeling YouSantana Featuring Michelle Branch & The Wreckers | 73 | Chart history → |
| 83 | RompeDaddy Yankee | 90 | Chart history → |
| 84 | Save MeShinedown | 87 | Chart history → |
| 85 | Just Might (Make Me Believe)Sugarland | 91 | Chart history → |
| 86 | UnpredictableJamie Foxx Featuring Ludacris | 100 | Chart history → |
| 87 | Confessions Of A Broken Heart (Daughter To Father)Lindsay Lohan | 58 | Chart history → |
| 88 | PresidentialYoungBloodZ | 88 | Chart history → |
| 89 | My Old FriendTim McGraw | 97 | Chart history → |
| 90 | Twisted TransistorKorn | 95 | Chart history → |
| 91 | Gotta GoTrey Songz | 96 | Chart history → |
| 92 | Looking For YouKirk Franklin | — | Chart history → |
| 93 | RodeoJuvenile | — | Chart history → |
| 94 | Redneck Yacht ClubCraig Morgan | 86 | Chart history → |
| 95 | Have A Nice DayBon Jovi | — | Chart history → |
| 96 | OnlyNine Inch Nails | 94 | Chart history → |
| 97 | RakataWisin & Yandel | — | Chart history → |
| 98 | Good Is GoodSheryl Crow | — | Chart history → |
| 99 | StrickenDisturbed | — | Chart history → |
| 100 | (I Never Promised You A) Rose GardenMartina McBride | 98 | Chart history → |