| 1 | I Wanna Love YouAkon Featuring Snoop Dogg | 1 | Chart history → |
| 2 | IrreplaceableBeyonce | 3 | Chart history → |
| 3 | Smack ThatAkon Featuring Eminem | 2 | Chart history → |
| 4 | My LoveJustin Timberlake Featuring T.I. | 4 | Chart history → |
| 5 | How To Save A LifeThe Fray | 8 | Chart history → |
| 6 | Lips Of An AngelHinder | 6 | Chart history → |
| 7 | Wind It UpGwen Stefani | 25 | Chart history → |
| 8 | Money MakerLudacris Featuring Pharrell | 7 | Chart history → |
| 9 | Chasing CarsSnow Patrol | 9 | Chart history → |
| 10 | FergaliciousFergie | 5 | Chart history → |
| 11 | Shortie Like MineBow Wow Featuring Chris Brown & Johnta Austin | 10 | Chart history → |
| 12 | We Fly HighJim Jones | 16 | Chart history → |
| 13 | Show Me What You GotJAY-Z | 13 | Chart history → |
| 14 | SexyBackJustin Timberlake | 11 | Listen & explore → |
| 15 | It Ends TonightThe All-American Rejects | 12 | Chart history → |
| 16 | Say GoodbyeChris Brown | 14 | Chart history → |
| 17 | Far AwayNickelback | 15 | Chart history → |
| 18 | Walk It OutUnk | 18 | Chart history → |
| 19 | Before He CheatsCarrie Underwood | 19 | Chart history → |
| 20 | That's ThatSnoop Dogg Featuring R. Kelly | 85 | Chart history → |
| 21 | HurtChristina Aguilera | 23 | Chart history → |
| 22 | Too Little Too LateJoJo | 17 | Chart history → |
| 23 | Waiting On The World To ChangeJohn Mayer | 22 | Chart history → |
| 24 | Call Me When You're SoberEvanescence | 20 | Chart history → |
| 25 | Say It RightNelly Furtado | 66 | Listen & explore → |
| 26 | Come To MeDiddy Featuring Nicole Scherzinger | 21 | Chart history → |
| 27 | Stuntin' Like My DaddyBirdman & Lil Wayne | 24 | Chart history → |
| 28 | Walk Away (Remember Me)Paula DeAnda Featuring The DEY | 30 | Chart history → |
| 29 | Show StopperDanity Kane | 26 | Chart history → |
| 30 | Welcome To The Black ParadeMy Chemical Romance | 27 | Chart history → |
| 31 | PromiseCiara | 34 | Chart history → |
| 32 | Money In The BankLil Scrappy Featuring Young Buck | 29 | Chart history → |
| 33 | My WishRascal Flatts | 31 | Chart history → |
| 34 | Get UpCiara Featuring Chamillionaire | 28 | Chart history → |
| 35 | Want ToSugarland | 33 | Chart history → |
| 36 | ButtonsThe Pussycat Dolls Featuring Snoop Dogg | 37 | Chart history → |
| 37 | She's EverythingBrad Paisley | 35 | Chart history → |
| 38 | What Hurts The MostRascal Flatts | 40 | Chart history → |
| 39 | My Little GirlTim McGraw | 38 | Chart history → |
| 40 | Make It RainFat Joe Featuring Lil Wayne | 47 | Chart history → |
| 41 | Wait A MinuteThe Pussycat Dolls Featuring Timbaland | 53 | Chart history → |
| 42 | White & Nerdy"Weird Al" Yankovic | 36 | Chart history → |
| 43 | You Save MeKenny Chesney | 41 | Chart history → |
| 44 | Over My Head (Cable Car)The Fray | 42 | Chart history → |
| 45 | Tim McGrawTaylor Swift | 48 | Chart history → |
| 46 | Suddenly I SeeKT Tunstall | 45 | Chart history → |
| 47 | UnappreciatedCherish | 50 | Chart history → |
| 48 | When You Were YoungThe Killers | 39 | Chart history → |
| 49 | Through GlassStone Sour | 51 | Chart history → |
| 50 | Chain Hang LowJibbs | 44 | Chart history → |
| 51 | The Saints Are ComingU2 & Green Day | 65 | Chart history → |
| 52 | Tell MeDiddy Featuring Christina Aguilera | 55 | Chart history → |
| 53 | ManeaterNelly Furtado | 52 | Chart history → |
| 54 | Let's RideThe Game | 46 | Chart history → |
| 55 | Come Back To MeVanessa Hudgens | 61 | Chart history → |
| 56 | Watching YouRodney Atkins | 62 | Chart history → |
| 57 | I Loved Her FirstHeartland | 56 | Chart history → |
| 58 | About UsBrooke Hogan Featuring Paul Wall | 58 | Chart history → |
| 59 | Dem JeansChingy Featuring Jermaine Dupri | 69 | Chart history → |
| 60 | Some People ChangeMontgomery Gentry | 64 | Chart history → |
| 61 | GalleryMario Vazquez | 57 | Chart history → |
| 62 | Here (In Your Arms)Hellogoodbye | 83 | Chart history → |
| 63 | It Just Comes NaturalGeorge Strait | 73 | Chart history → |
| 64 | Streetcorner SymphonyRob Thomas | 68 | Chart history → |
| 65 | It's Not OverDaughtry | — | Chart history → |
| 66 | BostonAugustana | 67 | Chart history → |
| 67 | Once In A LifetimeKeith Urban | 49 | Chart history → |
| 68 | Take Me As I AmMary J. Blige | 60 | Chart history → |
| 69 | Runaway LoveLudacris Featuring Mary J. Blige | 91 | Chart history → |
| 70 | Love Me Or Hate Me (F**k You!!!!)Lady Sovereign | 54 | Chart history → |
| 71 | Ring The AlarmBeyonce | 59 | Chart history → |
| 72 | Hate (I Really Don't Like You)Plain White T's | 70 | Chart history → |
| 73 | Amarillo SkyJason Aldean | 80 | Chart history → |
| 74 | YouLloyd Featuring Lil Wayne | 86 | Chart history → |
| 75 | London BridgeFergie | 32 | Chart history → |
| 76 | Push ItRick Ross | 63 | Chart history → |
| 77 | RockstarNickelback | 77 | Chart history → |
| 78 | Upgrade UBeyonce Featuring Jay Z | 84 | Chart history → |
| 79 | You Know My NameChris Cornell | — | Chart history → |
| 80 | Here It Goes AgainOK Go | 74 | Chart history → |
| 81 | Tu AmorRBD | 72 | Chart history → |
| 82 | MountainsLonestar | 82 | Chart history → |
| 83 | The Kill (Bury Me)30 Seconds To Mars | 87 | Chart history → |
| 84 | I Luv ItYoung Jeezy | 100 | Chart history → |
| 85 | Need A BossShareefa Featuring Ludacris | 78 | Chart history → |
| 86 | Every Mile A MemoryDierks Bentley | 75 | Chart history → |
| 87 | Give It AwayGeorge Strait | 79 | Chart history → |
| 88 | S.E.X.Lyfe Jennings | 81 | Chart history → |
| 89 | Tell Me BabyRed Hot Chili Peppers | 88 | Chart history → |
| 90 | I Call It LoveLionel Richie | 76 | Chart history → |
| 91 | It's Okay (One Blood)The Game Featuring Junior Reid | 71 | Chart history → |
| 92 | Snow ((Hey Oh))Red Hot Chili Peppers | — | Chart history → |
| 93 | Face DownThe Red Jumpsuit Apparatus | 98 | Chart history → |
| 94 | The Diary Of JaneBreaking Benjamin | 90 | Chart history → |
| 95 | Break It OffRihanna & Sean Paul | — | Chart history → |
| 96 | Greatest Time Of YearAly & AJ | — | Chart history → |
| 97 | Ay Chico (Lengua Afuera)Pitbull | — | Chart history → |
| 98 | Kingdom ComeJAY-Z | — | Chart history → |
| 99 | Save RoomJohn Legend | 93 | Chart history → |
| 100 | Chicken Noodle Soup.Webstar & Young B Featuring The Voice Of Harlem | 94 | Chart history → |