| 1 | IrreplaceableBeyonce | 1 | Chart history → |
| 2 | I Wanna Love YouAkon Featuring Snoop Dogg | 2 | Chart history → |
| 3 | FergaliciousFergie | 4 | Chart history → |
| 4 | Smack ThatAkon Featuring Eminem | 3 | Chart history → |
| 5 | My LoveJustin Timberlake Featuring T.I. | 5 | Chart history → |
| 6 | Say It RightNelly Furtado | 12 | Listen & explore → |
| 7 | Wind It UpGwen Stefani | 6 | Chart history → |
| 8 | We Fly HighJim Jones | 10 | Chart history → |
| 9 | How To Save A LifeThe Fray | 7 | Chart history → |
| 10 | Shortie Like MineBow Wow Featuring Chris Brown & Johnta Austin | 9 | Chart history → |
| 11 | Lips Of An AngelHinder | 8 | Chart history → |
| 12 | You Don't KnowEminem, 50 Cent, Lloyd Banks & Ca$his | — | Chart history → |
| 13 | Money MakerLudacris Featuring Pharrell | 11 | Chart history → |
| 14 | PromiseCiara | 23 | Chart history → |
| 15 | Walk It OutUnk | 14 | Chart history → |
| 16 | It Ends TonightThe All-American Rejects | 15 | Chart history → |
| 17 | Keep Holding OnAvril Lavigne | 22 | Chart history → |
| 18 | SexyBackJustin Timberlake | 18 | Listen & explore → |
| 19 | Chasing CarsSnow Patrol | 13 | Chart history → |
| 20 | Far AwayNickelback | 16 | Chart history → |
| 21 | HurtChristina Aguilera | 19 | Chart history → |
| 22 | I Luv ItYoung Jeezy | 39 | Chart history → |
| 23 | Say GoodbyeChris Brown | 17 | Chart history → |
| 24 | Before He CheatsCarrie Underwood | 21 | Chart history → |
| 25 | That's ThatSnoop Dogg Featuring R. Kelly | 20 | Chart history → |
| 26 | Walk Away (Remember Me)Paula DeAnda Featuring The DEY | 24 | Chart history → |
| 27 | Welcome To The Black ParadeMy Chemical Romance | 29 | Chart history → |
| 28 | Money In The BankLil Scrappy Featuring Young Buck | 31 | Chart history → |
| 29 | Waiting On The World To ChangeJohn Mayer | 27 | Chart history → |
| 30 | Make It RainFat Joe Featuring Lil Wayne | 33 | Chart history → |
| 31 | Call Me When You're SoberEvanescence | 26 | Chart history → |
| 32 | YouLloyd Featuring Lil Wayne | 61 | Chart history → |
| 33 | My WishRascal Flatts | 32 | Chart history → |
| 34 | Too Little Too LateJoJo | 28 | Chart history → |
| 35 | She's EverythingBrad Paisley | 35 | Chart history → |
| 36 | Stuntin' Like My DaddyBirdman & Lil Wayne | 30 | Chart history → |
| 37 | Show Me What You GotJAY-Z | 25 | Chart history → |
| 38 | Want ToSugarland | 36 | Chart history → |
| 39 | Wait A MinuteThe Pussycat Dolls Featuring Timbaland | 40 | Chart history → |
| 40 | My Little GirlTim McGraw | 38 | Chart history → |
| 41 | Runaway LoveLudacris Featuring Mary J. Blige | 53 | Chart history → |
| 42 | Get UpCiara Featuring Chamillionaire | 42 | Chart history → |
| 43 | Come To MeDiddy Featuring Nicole Scherzinger | 34 | Chart history → |
| 44 | Through GlassStone Sour | 45 | Chart history → |
| 45 | Watching YouRodney Atkins | 48 | Chart history → |
| 46 | Tim McGrawTaylor Swift | 44 | Chart history → |
| 47 | London BridgeFergie | 49 | Chart history → |
| 48 | UnappreciatedCherish | 41 | Chart history → |
| 49 | Tell MeDiddy Featuring Christina Aguilera | 50 | Chart history → |
| 50 | What Hurts The MostRascal Flatts | 47 | Chart history → |
| 51 | It's Not OverDaughtry | 51 | Chart history → |
| 52 | When You Were YoungThe Killers | 52 | Chart history → |
| 53 | Show StopperDanity Kane | 37 | Chart history → |
| 54 | A Great Big SledThe Killers Featuring Toni Halliday | — | Chart history → |
| 55 | You Save MeKenny Chesney | 43 | Chart history → |
| 56 | Snow ((Hey Oh))Red Hot Chili Peppers | 67 | Chart history → |
| 57 | White & Nerdy"Weird Al" Yankovic | 55 | Chart history → |
| 58 | It Just Comes NaturalGeorge Strait | 58 | Chart history → |
| 59 | Upgrade UBeyonce Featuring Jay Z | 64 | Chart history → |
| 60 | Some People ChangeMontgomery Gentry | 57 | Chart history → |
| 61 | ManeaterNelly Furtado | 54 | Chart history → |
| 62 | Come Back To MeVanessa Hudgens | 59 | Chart history → |
| 63 | Break It OffRihanna & Sean Paul | 71 | Chart history → |
| 64 | What Goes Around...Comes AroundJustin Timberlake | — | Chart history → |
| 65 | Let's RideThe Game | 56 | Chart history → |
| 66 | Lost OneJay-Z Featuring Chrisette Michele | — | Chart history → |
| 67 | Dem JeansChingy Featuring Jermaine Dupri | 62 | Chart history → |
| 68 | Amarillo SkyJason Aldean | 69 | Chart history → |
| 69 | Ice BoxOmarion | 81 | Chart history → |
| 70 | Anna-MollyIncubus | 66 | Chart history → |
| 71 | The Saints Are ComingU2 & Green Day | 60 | Chart history → |
| 72 | Streetcorner SymphonyRob Thomas | 65 | Chart history → |
| 73 | Poppin'Chris Brown Featuring Jay Biz | 82 | Chart history → |
| 74 | BostonAugustana | 70 | Chart history → |
| 75 | Here (In Your Arms)Hellogoodbye | 73 | Chart history → |
| 76 | Hip Hop Is DeadNas Featuring will.i.am | — | Chart history → |
| 77 | RockstarNickelback | 74 | Chart history → |
| 78 | RiverSarah McLachlan | — | Chart history → |
| 79 | Chain Hang LowJibbs | 63 | Chart history → |
| 80 | I Loved Her FirstHeartland | 68 | Chart history → |
| 81 | ZoomLil' Boosie Featuring Yung Joc | 78 | Chart history → |
| 82 | Take Me As I AmMary J. Blige | 72 | Chart history → |
| 83 | Face DownThe Red Jumpsuit Apparatus | 76 | Chart history → |
| 84 | MountainsLonestar | 77 | Chart history → |
| 85 | Into The OceanBlue October | — | Chart history → |
| 86 | PainThree Days Grace | 98 | Chart history → |
| 87 | Here It Goes AgainOK Go | 75 | Chart history → |
| 88 | Top BackT.I. | — | Chart history → |
| 89 | Tu RecuerdoRicky Martin Featuring La Mari De Chambao Y Tommy Torres | 96 | Chart history → |
| 90 | Ladies Love Country BoysTrace Adkins | — | Chart history → |
| 91 | Nothing Left To LoseMat Kearney | — | Chart history → |
| 92 | Lost Without URobin Thicke | — | Chart history → |
| 93 | Ay Chico (Lengua Afuera)Pitbull | 92 | Chart history → |
| 94 | Little Bit Of LifeCraig Morgan | 100 | Chart history → |
| 95 | Stupid BoyKeith Urban | — | Chart history → |
| 96 | One Wing In The FireTrent Tomlinson | — | Chart history → |
| 97 | The Diary Of JaneBreaking Benjamin | 93 | Chart history → |
| 98 | Red High HeelsKellie Pickler | — | Chart history → |
| 99 | Give It AwayGeorge Strait | 91 | Chart history → |
| 100 | Throw Some D'sRich Boy Featuring Polow Da Don | — | Chart history → |