| 1 | IrreplaceableBeyonce | 1 | Chart history → |
| 2 | I Wanna Love YouAkon Featuring Snoop Dogg | 2 | Chart history → |
| 3 | FergaliciousFergie | 4 | Chart history → |
| 4 | Smack ThatAkon Featuring Eminem | 3 | Chart history → |
| 5 | My LoveJustin Timberlake Featuring T.I. | 5 | Chart history → |
| 6 | Say It RightNelly Furtado | 6 | Listen & explore → |
| 7 | How To Save A LifeThe Fray | 8 | Chart history → |
| 8 | We Fly HighJim Jones | 7 | Chart history → |
| 9 | Shortie Like MineBow Wow Featuring Chris Brown & Johnta Austin | 9 | Chart history → |
| 10 | Lips Of An AngelHinder | 10 | Chart history → |
| 11 | It Ends TonightThe All-American Rejects | 18 | Chart history → |
| 12 | SexyBackJustin Timberlake | 16 | Listen & explore → |
| 13 | Walk It OutUnk | 13 | Chart history → |
| 14 | PromiseCiara | 11 | Chart history → |
| 15 | Money MakerLudacris Featuring Pharrell | 15 | Chart history → |
| 16 | Welcome To The Black ParadeMy Chemical Romance | 27 | Chart history → |
| 17 | Chasing CarsSnow Patrol | 17 | Chart history → |
| 18 | Walk Away (Remember Me)Paula DeAnda Featuring The DEY | 22 | Chart history → |
| 19 | Far AwayNickelback | 20 | Chart history → |
| 20 | Keep Holding OnAvril Lavigne | 19 | Chart history → |
| 21 | Wind It UpGwen Stefani | 12 | Chart history → |
| 22 | Runaway LoveLudacris Featuring Mary J. Blige | 31 | Chart history → |
| 23 | What Goes Around...Comes AroundJustin Timberlake | 38 | Chart history → |
| 24 | Before He CheatsCarrie Underwood | 23 | Chart history → |
| 25 | HurtChristina Aguilera | 21 | Chart history → |
| 26 | I Luv ItYoung Jeezy | 14 | Chart history → |
| 27 | Make It RainFat Joe Featuring Lil Wayne | 30 | Chart history → |
| 28 | Waiting On The World To ChangeJohn Mayer | 29 | Chart history → |
| 29 | YouLloyd Featuring Lil Wayne | 26 | Chart history → |
| 30 | Say GoodbyeChris Brown | 28 | Chart history → |
| 31 | Snow ((Hey Oh))Red Hot Chili Peppers | 49 | Chart history → |
| 32 | That's ThatSnoop Dogg Featuring R. Kelly | 24 | Chart history → |
| 33 | Too Little Too LateJoJo | 35 | Chart history → |
| 34 | Money In The BankLil Scrappy Featuring Young Buck | 32 | Chart history → |
| 35 | Wait A MinuteThe Pussycat Dolls Featuring Timbaland | 37 | Chart history → |
| 36 | Call Me When You're SoberEvanescence | 34 | Chart history → |
| 37 | My WishRascal Flatts | 33 | Chart history → |
| 38 | It's Not OverDaughtry | 44 | Chart history → |
| 39 | Through GlassStone Sour | 41 | Chart history → |
| 40 | She's EverythingBrad Paisley | 36 | Chart history → |
| 41 | Hip Hop Is DeadNas Featuring will.i.am | 56 | Chart history → |
| 42 | Here It Goes AgainOK Go | 62 | Chart history → |
| 43 | Suddenly I SeeKT Tunstall | — | Chart history → |
| 44 | White & Nerdy"Weird Al" Yankovic | 55 | Chart history → |
| 45 | Watching YouRodney Atkins | 40 | Chart history → |
| 46 | What Hurts The MostRascal Flatts | 46 | Chart history → |
| 47 | My Little GirlTim McGraw | 43 | Chart history → |
| 48 | Tim McGrawTaylor Swift | 45 | Chart history → |
| 49 | Stuntin' Like My DaddyBirdman & Lil Wayne | 42 | Chart history → |
| 50 | You Don't KnowEminem, 50 Cent, Lloyd Banks & Ca$his | 25 | Chart history → |
| 51 | Tell MeDiddy Featuring Christina Aguilera | 47 | Chart history → |
| 52 | Want ToSugarland | 39 | Chart history → |
| 53 | Ice BoxOmarion | 57 | Chart history → |
| 54 | Show StopperDanity Kane | 53 | Chart history → |
| 55 | Top BackT.I. | 83 | Chart history → |
| 56 | Here (In Your Arms)Hellogoodbye | 63 | Chart history → |
| 57 | When You Were YoungThe Killers | 59 | Chart history → |
| 58 | Lost OneJay-Z Featuring Chrisette Michele | 60 | Chart history → |
| 59 | ManeaterNelly Furtado | 61 | Chart history → |
| 60 | Show Me What You GotJAY-Z | 52 | Chart history → |
| 61 | Come To MeDiddy Featuring Nicole Scherzinger | 48 | Chart history → |
| 62 | RockstarNickelback | 72 | Chart history → |
| 63 | Poppin'Chris Brown Featuring Jay Biz | 64 | Chart history → |
| 64 | Break It OffRihanna & Sean Paul | 54 | Chart history → |
| 65 | UnappreciatedCherish | 51 | Chart history → |
| 66 | Into The OceanBlue October | 66 | Chart history → |
| 67 | BostonAugustana | 69 | Chart history → |
| 68 | ZoomLil' Boosie Featuring Yung Joc | 70 | Chart history → |
| 69 | Face DownThe Red Jumpsuit Apparatus | 78 | Chart history → |
| 70 | It Just Comes NaturalGeorge Strait | 58 | Chart history → |
| 71 | Amarillo SkyJason Aldean | 65 | Chart history → |
| 72 | The Sweet EscapeGwen Stefani Featuring Akon | 93 | Chart history → |
| 73 | PainThree Days Grace | 80 | Chart history → |
| 74 | Stupid BoyKeith Urban | 82 | Chart history → |
| 75 | You Save MeKenny Chesney | 68 | Chart history → |
| 76 | Throw Some D'sRich Boy Featuring Polow Da Don | 86 | Chart history → |
| 77 | Love Like WinterAFI | 88 | Chart history → |
| 78 | Upgrade UBeyonce Featuring Jay Z | 74 | Chart history → |
| 79 | Anna-MollyIncubus | 77 | Chart history → |
| 80 | The Saints Are ComingU2 & Green Day | 75 | Chart history → |
| 81 | Streetcorner SymphonyRob Thomas | 73 | Chart history → |
| 82 | Red High HeelsKellie Pickler | 94 | Chart history → |
| 83 | Ladies Love Country BoysTrace Adkins | 90 | Chart history → |
| 84 | FidelityRegina Spektor | 98 | Chart history → |
| 85 | RiverSarah McLachlan | 71 | Chart history → |
| 86 | The Way I LiveBaby Boy Da Prince Featuring Lil Boosie | 100 | Chart history → |
| 87 | Nothing Left To LoseMat Kearney | 92 | Chart history → |
| 88 | A Great Big SledThe Killers Featuring Toni Halliday | — | Chart history → |
| 89 | Happy Xmas (War Is Over)The Fray | 50 | Chart history → |
| 90 | I Loved Her FirstHeartland | 87 | Chart history → |
| 91 | Come Back To MeVanessa Hudgens | 79 | Chart history → |
| 92 | Some People ChangeMontgomery Gentry | 67 | Chart history → |
| 93 | Take Me As I AmMary J. Blige | 76 | Chart history → |
| 94 | Lost Without URobin Thicke | 91 | Chart history → |
| 95 | ListenBeyonce | — | Chart history → |
| 96 | Dem JeansChingy Featuring Jermaine Dupri | 85 | Chart history → |
| 97 | On The HotlinePretty Ricky | — | Chart history → |
| 98 | Ay Chico (Lengua Afuera)Pitbull | 96 | Chart history → |
| 99 | Tell Me BabyRed Hot Chili Peppers | — | Chart history → |
| 100 | Tu AmorRBD | — | Chart history → |