| 1 | Give It To MeTimbaland Featuring Nelly Furtado & Justin Timberlake | 1 | Chart history → |
| 2 | Don't MatterAkon | 2 | Chart history → |
| 3 | GirlfriendAvril Lavigne | 6 | Chart history → |
| 4 | GlamorousFergie Featuring Ludacris | 4 | Chart history → |
| 5 | The Sweet EscapeGwen Stefani Featuring Akon | 3 | Chart history → |
| 6 | This Is Why I'm HotMims | 5 | Chart history → |
| 7 | Buy U A Drank (Shawty Snappin')T-Pain Featuring Yung Joc | 10 | Chart history → |
| 8 | Beautiful LiarBeyonce & Shakira | 9 | Chart history → |
| 9 | Cupid's Chokehold/Breakfast In AmericaGym Class Heroes Featuring Patrick Stump | 8 | Chart history → |
| 10 | Last NightDiddy Featuring Keyshia Cole | 11 | Chart history → |
| 11 | U + Ur HandP!nk | 14 | Chart history → |
| 12 | I'm A FlirtR. Kelly Or Bow Wow (Featuring T.I. & T-Pain) | 15 | Chart history → |
| 13 | What I've DoneLinkin Park | 7 | Chart history → |
| 14 | It's Not OverDaughtry | 12 | Chart history → |
| 15 | Before He CheatsCarrie Underwood | 22 | Chart history → |
| 16 | What Goes Around...Comes AroundJustin Timberlake | 13 | Chart history → |
| 17 | Say It RightNelly Furtado | 16 | Listen & explore → |
| 18 | If Everyone CaredNickelback | 20 | Chart history → |
| 19 | Go GettaYoung Jeezy Featuring R. Kelly | 18 | Chart history → |
| 20 | Lost Without URobin Thicke | 19 | Chart history → |
| 21 | The Way I LiveBaby Boy Da Prince Featuring Lil Boosie | 26 | Chart history → |
| 22 | Like A BoyCiara | 25 | Chart history → |
| 23 | Pop, Lock & Drop ItHuey | 30 | Chart history → |
| 24 | Face DownThe Red Jumpsuit Apparatus | 27 | Chart history → |
| 25 | Last Dollar (Fly Away)Tim McGraw | 17 | Chart history → |
| 26 | Ice BoxOmarion | 23 | Chart history → |
| 27 | Throw Some D'sRich Boy Featuring Polow Da Don | 21 | Chart history → |
| 28 | With LoveHilary Duff | 24 | Chart history → |
| 29 | 2 StepUnk | 31 | Chart history → |
| 30 | IrreplaceableBeyonce | 28 | Chart history → |
| 31 | HomeDaughtry | 43 | Chart history → |
| 32 | Outta My SystemBow Wow Featuring T-Pain & Johnta Austin | 39 | Chart history → |
| 33 | Better Than MeHinder | 40 | Chart history → |
| 34 | Rock Yo HipsCrime Mob Featuring Lil Scrappy | 36 | Chart history → |
| 35 | I TriedBone Thugs-N-Harmony Featuring Akon | 78 | Chart history → |
| 36 | Get It ShawtyLloyd | 44 | Chart history → |
| 37 | How To Save A LifeThe Fray | 37 | Chart history → |
| 38 | This Ain't A Scene, It's An Arms RaceFall Out Boy | 29 | Chart history → |
| 39 | Walk It OutUnk | 38 | Chart history → |
| 40 | Over ItKatharine McPhee | 34 | Chart history → |
| 41 | YouLloyd Featuring Lil Wayne | 33 | Chart history → |
| 42 | Make It RainFat Joe Featuring Lil Wayne | 32 | Chart history → |
| 43 | WastedCarrie Underwood | 42 | Chart history → |
| 44 | CandymanChristina Aguilera | 35 | Chart history → |
| 45 | We Takin' OverDJ Khaled Featuring T.I., Akon, Rick Ross, Fat Joe, Lil' Wayne & Baby | 63 | Chart history → |
| 46 | I Wanna Love YouAkon Featuring Snoop Dogg | 41 | Chart history → |
| 47 | Because Of YouNe-Yo | 46 | Chart history → |
| 48 | BuddyMusiq Soulchild | 45 | Chart history → |
| 49 | Smack ThatAkon Featuring Eminem | 48 | Chart history → |
| 50 | Waiting On The World To ChangeJohn Mayer | 47 | Chart history → |
| 51 | TicksBrad Paisley | 50 | Chart history → |
| 52 | Teardrops On My GuitarTaylor Swift | 60 | Chart history → |
| 53 | Hey There DelilahPlain White T's | 66 | Chart history → |
| 54 | StandRascal Flatts | 61 | Chart history → |
| 55 | Good DirectionsBilly Currington | 68 | Chart history → |
| 56 | Doe Boy FreshThree 6 Mafia Featuring Chamillionaire | 54 | Chart history → |
| 57 | Settlin'Sugarland | 58 | Chart history → |
| 58 | Break It OffRihanna & Sean Paul | 51 | Chart history → |
| 59 | Keep Holding OnAvril Lavigne | 55 | Chart history → |
| 60 | Lost In This MomentBig & Rich | 75 | Chart history → |
| 61 | Top BackT.I. | 57 | Chart history → |
| 62 | She's Like The WindLumidee Featuring Tony Sunshine | 53 | Chart history → |
| 63 | StolenDashboard Confessional | 65 | Chart history → |
| 64 | AnywayMartina McBride | 52 | Chart history → |
| 65 | Read My MindThe Killers | 62 | Chart history → |
| 66 | On The HotlinePretty Ricky | 56 | Chart history → |
| 67 | Thnks Fr Th MmrsFall Out Boy | — | Chart history → |
| 68 | Grace KellyMIKA | 59 | Chart history → |
| 69 | Little WondersRob Thomas | 73 | Chart history → |
| 70 | Look After YouThe Fray | 64 | Chart history → |
| 71 | PainThree Days Grace | 70 | Chart history → |
| 72 | Into The OceanBlue October | 69 | Chart history → |
| 73 | Beer In MexicoKenny Chesney | 67 | Chart history → |
| 74 | Summer LoveJustin Timberlake | — | Chart history → |
| 75 | The Story (I Was Made For You)Brandi Carlile | — | Chart history → |
| 76 | Long Trip AloneDierks Bentley | 79 | Chart history → |
| 77 | Poppin'Chris Brown Featuring Jay Biz | 72 | Chart history → |
| 78 | Makes Me WonderMaroon 5 | 84 | Chart history → |
| 79 | High Maintenance WomanToby Keith | 80 | Chart history → |
| 80 | ForeverPapa Roach | 90 | Chart history → |
| 81 | Like ThisKelly Rowland Featuring Eve | 89 | Chart history → |
| 82 | MomentsEmerson Drive | 82 | Chart history → |
| 83 | Stupid BoyKeith Urban | 74 | Chart history → |
| 84 | Earth IntrudersBjork | — | Chart history → |
| 85 | Upgrade UBeyonce Featuring Jay Z | 76 | Chart history → |
| 86 | Que HicisteJennifer Lopez | — | Chart history → |
| 87 | I'll Wait For YouJoe Nichols | 77 | Chart history → |
| 88 | A Woman's LoveAlan Jackson | 88 | Chart history → |
| 89 | Find Out Who Your Friends AreTracy Lawrence | 94 | Chart history → |
| 90 | Please Don't GoTank | 92 | Chart history → |
| 91 | UmbrellaRihanna Featuring Jay-Z | — | Chart history → |
| 92 | ApologizeTimbaland Featuring OneRepublic | 95 | Chart history → |
| 93 | The RiverGood Charlotte Featuring M. Shadows And Synyster Gates | 71 | Chart history → |
| 94 | I'm ThrowedPaul Wall Featuring Jermaine Dupri | — | Chart history → |
| 95 | Ladies Love Country BoysTrace Adkins | 87 | Chart history → |
| 96 | BreathBreaking Benjamin | 93 | Chart history → |
| 97 | SmileLily Allen | 97 | Chart history → |
| 98 | Kiss The GirlAshley Tisdale | 81 | Chart history → |
| 99 | When I See UFantasia | 99 | Chart history → |
| 100 | It's Me SnitchesSwizz Beatz | — | Chart history → |