| 1 | No OneAlicia Keys | 2 | Chart history → |
| 2 | Kiss KissChris Brown Featuring T-Pain | 1 | Chart history → |
| 3 | ApologizeTimbaland Featuring OneRepublic | 3 | Chart history → |
| 4 | LowFlo Rida Featuring T-Pain | 6 | Chart history → |
| 5 | BubblyColbie Caillat | 5 | Chart history → |
| 6 | Crank That (Soulja Boy)Soulja Boy Tell'em | 4 | Chart history → |
| 7 | Good LifeKanye West Featuring T-Pain | 7 | Chart history → |
| 8 | ClumsyFergie | 12 | Chart history → |
| 9 | CycloneBaby Bash Featuring T-Pain | 8 | Chart history → |
| 10 | StrongerKanye West | 9 | Chart history → |
| 11 | ParalyzerFinger Eleven | 10 | Chart history → |
| 12 | Hate That I Love YouRihanna Featuring Ne-Yo | 11 | Chart history → |
| 13 | The Way I AreTimbaland Featuring Keri Hilson | 13 | Listen & explore → |
| 14 | BedJ. Holiday | 14 | Chart history → |
| 15 | How Far We've Comematchbox twenty | 15 | Chart history → |
| 16 | TattooJordin Sparks | 18 | Chart history → |
| 17 | Big Girls Don't CryFergie | 16 | Chart history → |
| 18 | Shawty Is A 10The-Dream | 17 | Chart history → |
| 19 | Over YouDaughtry | 23 | Chart history → |
| 20 | Who KnewP!nk | 20 | Chart history → |
| 21 | Ayo Technology50 Cent Featuring Justin Timberlake & Timbaland | 19 | Chart history → |
| 22 | Duffle Bag BoyPlayaz Circle Featuring Lil Wayne | 22 | Chart history → |
| 23 | So SmallCarrie Underwood | 21 | Chart history → |
| 24 | I'm So HoodDJ Khaled Featuring T-Pain, Trick Daddy, Rick Ross & Plies | 25 | Chart history → |
| 25 | Wake Up CallMaroon 5 | 27 | Chart history → |
| 26 | Until The End Of TimeJustin Timberlake Duet With Beyonce | 30 | Chart history → |
| 27 | Love Like ThisNatasha Bedingfield Featuring Sean Kingston | 36 | Chart history → |
| 28 | Our SongTaylor Swift | 24 | Chart history → |
| 29 | Gimme MoreBritney Spears | 26 | Listen & explore → |
| 30 | Can't Help But WaitTrey Songz | 37 | Chart history → |
| 31 | RockstarNickelback | 29 | Chart history → |
| 32 | HypnotizedPlies Featuring Akon | 34 | Chart history → |
| 33 | Don't BlinkKenny Chesney | 31 | Chart history → |
| 34 | Baby Don't GoFabolous Featuring Jermaine Dupri | 28 | Chart history → |
| 35 | I Don't Wanna Be In Love (Dance Floor Anthem)Good Charlotte | 38 | Chart history → |
| 36 | StaySugarland | 32 | Chart history → |
| 37 | Soulja GirlSoulja Boy Tell'em Featuring I-15 | 39 | Chart history → |
| 38 | Into The NightSantana Featuring Chad Kroeger | 40 | Chart history → |
| 39 | Hey There DelilahPlain White T's | 35 | Chart history → |
| 40 | My Drink N' My 2 StepCassidy Featuring Swizz Beatz | 33 | Chart history → |
| 41 | Get Buck In HereDJ Felli Fel Featuring Diddy, Akon, Ludacris & Lil Jon | 44 | Chart history → |
| 42 | Take You ThereSean Kingston | 63 | Chart history → |
| 43 | Just FineMary J. Blige | 53 | Chart history → |
| 44 | Sweetest Girl (Dollar Bill)Wyclef Jean Featuring Akon, Lil Wayne & Niia | 47 | Chart history → |
| 45 | Like You'll Never See Me AgainAlicia Keys | 93 | Chart history → |
| 46 | Let It GoKeyshia Cole Featuring Missy Elliott & Lil Kim | 41 | Chart history → |
| 47 | Before He CheatsCarrie Underwood | 43 | Chart history → |
| 48 | Misery BusinessParamore | 51 | Chart history → |
| 49 | Shoulda Let You GoKeyshia Cole Introducing Amina | 54 | Chart history → |
| 50 | UmbrellaRihanna Featuring Jay-Z | 46 | Chart history → |
| 51 | How 'Bout Them CowgirlsGeorge Strait | 52 | Chart history → |
| 52 | Free And Easy (Down The Road I Go)Dierks Bentley | 49 | Chart history → |
| 53 | FirecrackerJosh Turner | 50 | Chart history → |
| 54 | Taking ChancesCeline Dion | — | Chart history → |
| 55 | More Than A MemoryGarth Brooks | 59 | Chart history → |
| 56 | Livin' Our Love SongJason Michael Carroll | 57 | Chart history → |
| 57 | FallClay Walker | 60 | Chart history → |
| 58 | The PretenderFoo Fighters | 56 | Chart history → |
| 59 | Hood FiggaGorilla Zoe | 55 | Chart history → |
| 60 | LoveStonedJustin Timberlake | 58 | Chart history → |
| 61 | Take Me ThereRascal Flatts | 62 | Chart history → |
| 62 | GirlfriendBow Wow & Omarion | 69 | Chart history → |
| 63 | Music Is My Hot Hot SexCSS | 84 | Chart history → |
| 64 | Roc Boys (And The Winner Is)...JAY-Z | 77 | Chart history → |
| 65 | Ready, Set, Don't GoBilly Ray Cyrus With Miley Cyrus | 72 | Chart history → |
| 66 | OnlineBrad Paisley | 64 | Chart history → |
| 67 | Fake ItSeether | 71 | Chart history → |
| 68 | I'm Like A Lawyer...(Me & You)Fall Out Boy | 70 | Chart history → |
| 69 | Freaky GurlGucci Mane | 65 | Chart history → |
| 70 | Shadow Of The DayLinkin Park | 89 | Chart history → |
| 71 | EverybodyKeith Urban | 74 | Chart history → |
| 72 | As IfSara Evans | 67 | Chart history → |
| 73 | What Do Ya Think About ThatMontgomery Gentry | 75 | Chart history → |
| 74 | S.O.S.Jonas Brothers | 79 | Chart history → |
| 75 | Nothin' Better To DoLeAnn Rimes | 73 | Chart history → |
| 76 | If You're Reading ThisTim McGraw | 66 | Chart history → |
| 77 | Pictures Of YouThe Last Goodnight | 78 | Chart history → |
| 78 | Bleed It OutLinkin Park | 68 | Chart history → |
| 79 | Winner At A Losing GameRascal Flatts | 82 | Chart history → |
| 80 | Piece Of MeBritney Spears | 80 | Chart history → |
| 81 | Never Too LateThree Days Grace | 76 | Chart history → |
| 82 | Me EnamoraJuanes | 81 | Chart history → |
| 83 | Watching AirplanesGary Allan | 87 | Chart history → |
| 84 | SuffocateJ. Holiday | 96 | Chart history → |
| 85 | 1234Feist | 83 | Chart history → |
| 86 | Do It WellJennifer Lopez | 85 | Chart history → |
| 87 | Pop BottlesBirdman Featuring Lil Wayne | 95 | Chart history → |
| 88 | From Where You AreLifehouse | 61 | Chart history → |
| 89 | Letter To MeBrad Paisley | — | Chart history → |
| 90 | Love Me If You CanToby Keith | 88 | Chart history → |
| 91 | The Hand ClapHurricane Chris Featuring Big Poppa | 86 | Chart history → |
| 92 | Love SongSara Bareilles | 98 | Chart history → |
| 93 | Sorry, Blame It On MeAkon | 92 | Chart history → |
| 94 | Stealing CinderellaChuck Wicks | — | Chart history → |
| 95 | Me LoveSean Kingston | 94 | Chart history → |
| 96 | The Way I AmIngrid Michaelson | — | Chart history → |
| 97 | Calabria 2008Enur Featuring Natasja | — | Chart history → |
| 98 | I Get Money50 Cent | 99 | Chart history → |
| 99 | Sexy MovimientoWisin & Yandel | 100 | Chart history → |
| 100 | Dreaming With A Broken HeartJohn Mayer | — | Chart history → |