| 1 | Let Me Love YouMario | 1 | Chart history → |
| 2 | 1, 2 StepCiara Featuring Missy Elliott | 2 | Chart history → |
| 3 | Lovers And FriendsLil Jon & The East Side Boyz Featuring Usher & Ludacris | 4 | Chart history → |
| 4 | Drop It Like It's HotSnoop Dogg Featuring Pharrell | 3 | Chart history → |
| 5 | SoldierDestiny's Child Featuring T.I. & Lil Wayne | 5 | Chart history → |
| 6 | My BooUsher And Alicia Keys | 6 | Chart history → |
| 7 | Over And OverNelly Featuring Tim McGraw | 7 | Chart history → |
| 8 | Disco Inferno50 Cent | 8 | Chart history → |
| 9 | How We DoThe Game Featuring 50 Cent | 11 | Chart history → |
| 10 | I Don't Want To BeGavin DeGraw | 12 | Chart history → |
| 11 | Boulevard Of Broken DreamsGreen Day | 16 | Chart history → |
| 12 | BreakawayKelly Clarkson | 10 | Chart history → |
| 13 | Only UAshanti | 14 | Chart history → |
| 14 | WonderfulJa Rule Featuring R. Kelly & Ashanti | 9 | Chart history → |
| 15 | Get BackLudacris | 15 | Chart history → |
| 16 | Lose My BreathDestiny's Child | 13 | Chart history → |
| 17 | She Will Be LovedMaroon 5 | 17 | Chart history → |
| 18 | Bring Em OutT.I. | 18 | Chart history → |
| 19 | DaughtersJohn Mayer | 22 | Chart history → |
| 20 | TrueRyan Cabrera | 28 | Chart history → |
| 21 | KarmaLloyd Banks Featuring Avant | 21 | Chart history → |
| 22 | Since U Been GoneKelly Clarkson | 32 | Chart history → |
| 23 | Numb/EncoreJay-Z/Linkin Park | 23 | Chart history → |
| 24 | Beautiful SoulJesse McCartney | 34 | Chart history → |
| 25 | Let's GoTrick Daddy Featuring Lil Jon & Twista | 20 | Chart history → |
| 26 | GoodiesCiara Featuring Petey Pablo | 19 | Chart history → |
| 27 | What U Gon' DoLil Jon & The East Side Boyz Featuring Lil Scrappy | 24 | Chart history → |
| 28 | Dare You To MoveSwitchfoot | 25 | Chart history → |
| 29 | KarmaAlicia Keys | 36 | Chart history → |
| 30 | Awful, Beautiful LifeDarryl Worley | 41 | Chart history → |
| 31 | New YorkJa Rule Featuring Fat Joe & Jadakiss | 30 | Chart history → |
| 32 | CharleneAnthony Hamilton | 27 | Chart history → |
| 33 | U Make Me WannaJadakiss Featuring Mariah Carey | 33 | Chart history → |
| 34 | Some BeachBlake Shelton | 38 | Chart history → |
| 35 | GasolinaDaddy Yankee | 43 | Chart history → |
| 36 | Oye Mi CantoN.O.R.E. Featuring Daddy Yankee, Nina Sky, Gem Star & Big Mato | 26 | Chart history → |
| 37 | One ThingFinger Eleven | 29 | Chart history → |
| 38 | VertigoU2 | 40 | Chart history → |
| 39 | Back WhenTim McGraw | 42 | Chart history → |
| 40 | You're My Better HalfKeith Urban | 50 | Chart history → |
| 41 | Bless The Broken RoadRascal Flatts | 49 | Chart history → |
| 42 | Caught UpUsher | 58 | Chart history → |
| 43 | Mud On The TiresBrad Paisley | 53 | Chart history → |
| 44 | When I Think About Cheatin'Gretchen Wilson | 46 | Chart history → |
| 45 | On The Way DownRyan Cabrera | 37 | Chart history → |
| 46 | EncoreEminem, Dr. Dre & 50 Cent | 39 | Chart history → |
| 47 | LadyLenny Kravitz | 51 | Chart history → |
| 48 | Lean BackTerror Squad | 31 | Chart history → |
| 49 | BrokenSeether Featuring Amy Lee | 35 | Chart history → |
| 50 | Rich GirlGwen Stefani Featuring Eve | 57 | Chart history → |
| 51 | MockingbirdEminem | 73 | Chart history → |
| 52 | Nobody's HomeAvril Lavigne | 54 | Chart history → |
| 53 | Get RightJennifer Lopez | — | Chart history → |
| 54 | Give A Little BitGoo Goo Dolls | 55 | Chart history → |
| 55 | Sunday MorningMaroon 5 | 74 | Chart history → |
| 56 | Nothin 'Bout Love Makes SenseLeAnn Rimes | 59 | Chart history → |
| 57 | Some CutTrillville Featuring Cutty | 63 | Chart history → |
| 58 | Monday Morning ChurchAlan Jackson | 61 | Chart history → |
| 59 | Go D.J.Lil Wayne | 47 | Chart history → |
| 60 | Baby It's YouJoJo Featuring Bow Wow | 52 | Chart history → |
| 61 | BreatheFabolous | 45 | Chart history → |
| 62 | Shorty Wanna RideYoung Buck | 48 | Chart history → |
| 63 | Nothing On But The RadioGary Allan | 64 | Chart history → |
| 64 | He Gets That From MeReba McEntire | 72 | Chart history → |
| 65 | Ordinary PeopleJohn Legend | 76 | Chart history → |
| 66 | Let's Get BlownSnoop Dogg | 75 | Chart history → |
| 67 | Mr. MomLonestar | 71 | Chart history → |
| 68 | OOmarion | — | Chart history → |
| 69 | How Am I Doin'Dierks Bentley | 60 | Chart history → |
| 70 | Nothin' To LoseJosh Gracin | — | Chart history → |
| 71 | Welcome To My LifeSimple Plan | 56 | Chart history → |
| 72 | Party For TwoShania Twain With Billy Currington Or Mark McGrath | 70 | Chart history → |
| 73 | Truth IsFantasia | — | Chart history → |
| 74 | Tempted To TouchRupee | 68 | Chart history → |
| 75 | 1985Bowling For Soup | 67 | Chart history → |
| 76 | The Woman With YouKenny Chesney | 66 | Chart history → |
| 77 | U Don't Know MeT.I. | — | Chart history → |
| 78 | Holy WaterBig & Rich | 81 | Chart history → |
| 79 | Balla BabyChingy | 62 | Chart history → |
| 80 | Just Lose ItEminem | 65 | Chart history → |
| 81 | Baby GirlSugarland | 83 | Chart history → |
| 82 | So ColdBreaking Benjamin | 80 | Chart history → |
| 83 | BabyFabolous Featuring Mike Shorey | — | Chart history → |
| 84 | OkayNivea Featuring Lil Jon & YoungBloodZ | 88 | Chart history → |
| 85 | Fall To PiecesVelvet Revolver | 82 | Chart history → |
| 86 | Getting Away With MurderPapa Roach | 85 | Chart history → |
| 87 | I Changed My MindKeyshia Cole Featuring Shyne | 77 | Chart history → |
| 88 | Vitamin R (Leading Us Along)Chevelle | 79 | Chart history → |
| 89 | You're The OneGuerilla Black Featuring Mario Winans | 86 | Chart history → |
| 90 | Dangerously In LoveBeyonce | 89 | Chart history → |
| 91 | HushLL Cool J Featuring 7 Aurelius | 78 | Chart history → |
| 92 | GhettoAkon | 93 | Chart history → |
| 93 | I Smoke, I DrankBody Head Bangerz Featuring YoungBloodz | 94 | Chart history → |
| 94 | Come Home SoonSHeDAISY | 87 | Chart history → |
| 95 | Gotta Go SoloPatti LaBelle Featuring Ron Isley | 90 | Chart history → |
| 96 | What You Waiting For?Gwen Stefani | 91 | Chart history → |
| 97 | PerdidosMonchy & Alexandra | 96 | Chart history → |
| 98 | Take Me HomeTerror Squad | 92 | Chart history → |
| 99 | Hold You DownThe Alchemist Featuring Prodigy, Illa Ghee & Nina Sky | 95 | Chart history → |
| 100 | Sugar (Gimme Some)Trick Daddy Featuring Ludacris, Lil' Kim & Cee-Lo | — | Chart history → |