| 1 | So SickNe-Yo | 1 | Chart history → |
| 2 | TemperatureSean Paul | 2 | Chart history → |
| 3 | You're BeautifulJames Blunt | 3 | Chart history → |
| 4 | Be Without YouMary J. Blige | 4 | Chart history → |
| 5 | Bad DayDaniel Powter | 14 | Chart history → |
| 6 | I'm N Luv (Wit A Stripper)T-Pain Featuring Mike Jones | 6 | Chart history → |
| 7 | UnwrittenNatasha Bedingfield | 10 | Chart history → |
| 8 | Check On ItBeyonce Featuring Slim Thug | 5 | Chart history → |
| 9 | Lean Wit It, Rock Wit ItDem Franchize Boyz Featuring Lil Peanut & Charlay | 9 | Chart history → |
| 10 | Yo (Excuse Me Miss)Chris Brown | 8 | Chart history → |
| 11 | GrillzNelly Featuring Paul Wall, Ali & Gipp | 7 | Chart history → |
| 12 | Everytime We TouchCascada | 11 | Chart history → |
| 13 | Shake ThatEminem Featuring Nate Dogg | 12 | Chart history → |
| 14 | Ms. New BootyBubba Sparxxx Featuring Ying Yang Twins & Mr. ColliPark | 15 | Chart history → |
| 15 | UnpredictableJamie Foxx Featuring Ludacris | 13 | Chart history → |
| 16 | BeepThe Pussycat Dolls Featuring will.i.am | 25 | Chart history → |
| 17 | Dance, DanceFall Out Boy | 16 | Chart history → |
| 18 | Touch ItBusta Rhymes | 17 | Chart history → |
| 19 | Walk AwayKelly Clarkson | 26 | Chart history → |
| 20 | Jesus, Take The WheelCarrie Underwood | 24 | Chart history → |
| 21 | Dirty Little SecretThe All-American Rejects | 18 | Chart history → |
| 22 | Stupid GirlsP!nk | 19 | Chart history → |
| 23 | LoveKeyshia Cole | 20 | Chart history → |
| 24 | Pump ItThe Black Eyed Peas | 21 | Chart history → |
| 25 | My HumpsThe Black Eyed Peas | 28 | Chart history → |
| 26 | Because Of YouKelly Clarkson | 22 | Chart history → |
| 27 | Run It!Chris Brown | 23 | Chart history → |
| 28 | King Without A CrownMatisyahu | 61 | Chart history → |
| 29 | Fresh AzimizBow Wow Featuring J-Kwon & Jermaine Dupri | 32 | Chart history → |
| 30 | RompeDaddy Yankee | 31 | Chart history → |
| 31 | StickwituThe Pussycat Dolls | 27 | Chart history → |
| 32 | Who Says You Can't Go HomeBon Jovi | 34 | Chart history → |
| 33 | Always On Your SideSheryl Crow & Sting | 35 | Chart history → |
| 34 | Gold DiggerKanye West Featuring Jamie Foxx | 29 | Chart history → |
| 35 | PhotographNickelback | 33 | Chart history → |
| 36 | Ridin'Chamillionaire Featuring Krayzie Bone | 57 | Chart history → |
| 37 | Tonight I Wanna CryKeith Urban | 36 | Chart history → |
| 38 | Sugar, We're Goin' DownFall Out Boy | 39 | Chart history → |
| 39 | You And MeLifehouse | 37 | Chart history → |
| 40 | One WishRay J | 30 | Chart history → |
| 41 | RodeoJuvenile | 41 | Chart history → |
| 42 | Touch The SkyKanye West Featuring Lupe Fiasco | 47 | Chart history → |
| 43 | Feel Good IncGorillaz | 44 | Chart history → |
| 44 | SOSRihanna | 46 | Chart history → |
| 45 | Your ManJosh Turner | 38 | Chart history → |
| 46 | When I Get Where I'm GoingBrad Paisley Featuring Dolly Parton | 40 | Chart history → |
| 47 | Laffy TaffyD4L | 42 | Chart history → |
| 48 | We Be Burnin'Sean Paul | 45 | Chart history → |
| 49 | What Hurts The MostRascal Flatts | 66 | Chart history → |
| 50 | There It Go! (The Whistle Song)Juelz Santana | 43 | Chart history → |
| 51 | Move AlongThe All-American Rejects | 75 | Chart history → |
| 52 | Poppin' My CollarThree 6 Mafia | 72 | Chart history → |
| 53 | For You I Will (Confidence)Teddy Geiger | 55 | Chart history → |
| 54 | Girl Next DoorSaving Jane | 54 | Chart history → |
| 55 | Living In Fast ForwardKenny Chesney | 48 | Chart history → |
| 56 | Over My Head (Cable Car)The Fray | 64 | Chart history → |
| 57 | Ever The SameRob Thomas | 52 | Chart history → |
| 58 | Tell Me When To GoE-40 Featuring Keak Da Sneak | 73 | Chart history → |
| 59 | Upside DownJack Johnson | 51 | Chart history → |
| 60 | Best Friend50 Cent & Olivia | 60 | Chart history → |
| 61 | L.O.V.E.Ashlee Simpson | 50 | Chart history → |
| 62 | RushAly & AJ | 62 | Chart history → |
| 63 | Get Drunk And Be SomebodyToby Keith | 68 | Chart history → |
| 64 | In The DeepBird York | — | Chart history → |
| 65 | What You KnowT.I. | 83 | Chart history → |
| 66 | Goodbye My LoverJames Blunt | — | Chart history → |
| 67 | BelieveBrooks & Dunn | 69 | Chart history → |
| 68 | She Don't Tell Me ToMontgomery Gentry | 65 | Chart history → |
| 69 | Perfect SituationWeezer | 59 | Chart history → |
| 70 | Gotta GoTrey Songz | 82 | Chart history → |
| 71 | Looking For YouKirk Franklin | 71 | Chart history → |
| 72 | Nobody But MeBlake Shelton | 76 | Chart history → |
| 73 | What's Left Of MeNick Lachey | 67 | Chart history → |
| 74 | Oh Yes (aka 'Postman')Juelz Santana | 56 | Chart history → |
| 75 | Savin' MeNickelback | 94 | Chart history → |
| 76 | Cheatin'Sara Evans | 80 | Chart history → |
| 77 | SorryMadonna | 58 | Chart history → |
| 78 | Lights And SoundsYellowcard | 77 | Chart history → |
| 79 | Breaking FreeZac Efron, Andrew Seeley & Vanessa Anne Hudgens | 85 | Chart history → |
| 80 | Betcha Can't Do It Like MeD4L | 79 | Chart history → |
| 81 | When You're MadNe-Yo | 99 | Chart history → |
| 82 | I Write Sins Not TragediesPanic! At The Disco | 98 | Chart history → |
| 83 | GirlPaul Wall | 95 | Chart history → |
| 84 | CrashGwen Stefani | 70 | Chart history → |
| 85 | Bring Out The Freak In YouLil Rob | 90 | Chart history → |
| 86 | Can't Let GoAnthony Hamilton | 93 | Chart history → |
| 87 | KeroseneMiranda Lambert | 81 | Chart history → |
| 88 | WhyJason Aldean | 96 | Chart history → |
| 89 | In My MindHeather Headley | 84 | Chart history → |
| 90 | Nasty GirlThe Notorious B.I.G. Featuring Diddy, Nelly, Jagged Edge & Avery Storm | 78 | Chart history → |
| 91 | Black Horse & The Cherry TreeKT Tunstall | — | Chart history → |
| 92 | My HoodYoung Jeezy | 92 | Chart history → |
| 93 | Kryptonite (I'm On It)Purple Ribbon All-Stars | 86 | Chart history → |
| 94 | 4 MinutesAvant | — | Chart history → |
| 95 | Control MyselfLL Cool J Featuring Jennifer Lopez | 89 | Chart history → |
| 96 | DareGorillaz Featuring Shaun Ryder | — | Chart history → |
| 97 | Wherever You AreJack Ingram | — | Chart history → |
| 98 | The Real ThingBo Bice | — | Chart history → |
| 99 | TalkColdplay | — | Chart history → |
| 100 | Something's Gotta GiveLeAnn Rimes | — | Chart history → |