| 1 | No OneAlicia Keys | 1 | Chart history → |
| 2 | Kiss KissChris Brown Featuring T-Pain | 3 | Chart history → |
| 3 | ApologizeTimbaland Featuring OneRepublic | 2 | Chart history → |
| 4 | LowFlo Rida Featuring T-Pain | 4 | Chart history → |
| 5 | BubblyColbie Caillat | 6 | Chart history → |
| 6 | ClumsyFergie | 7 | Chart history → |
| 7 | Good LifeKanye West Featuring T-Pain | 8 | Chart history → |
| 8 | Crank That (Soulja Boy)Soulja Boy Tell'em | 5 | Chart history → |
| 9 | Hate That I Love YouRihanna Featuring Ne-Yo | 9 | Chart history → |
| 10 | ParalyzerFinger Eleven | 11 | Chart history → |
| 11 | TattooJordin Sparks | 12 | Chart history → |
| 12 | CycloneBaby Bash Featuring T-Pain | 10 | Chart history → |
| 13 | StrongerKanye West | 13 | Chart history → |
| 14 | The Way I AreTimbaland Featuring Keri Hilson | 14 | Listen & explore → |
| 15 | BedJ. Holiday | 16 | Chart history → |
| 16 | How Far We've Comematchbox twenty | 15 | Chart history → |
| 17 | Until The End Of TimeJustin Timberlake Duet With Beyonce | 33 | Chart history → |
| 18 | Duffle Bag BoyPlayaz Circle Featuring Lil Wayne | 17 | Chart history → |
| 19 | Can't Help But WaitTrey Songz | 25 | Chart history → |
| 20 | Love Like ThisNatasha Bedingfield Featuring Sean Kingston | 21 | Chart history → |
| 21 | HypnotizedPlies Featuring Akon | 24 | Chart history → |
| 22 | Over YouDaughtry | 18 | Chart history → |
| 23 | Shawty Is A 10The-Dream | 19 | Chart history → |
| 24 | Our SongTaylor Swift | 23 | Chart history → |
| 25 | I'm So HoodDJ Khaled Featuring T-Pain, Trick Daddy, Rick Ross & Plies | 22 | Chart history → |
| 26 | Just FineMary J. Blige | 36 | Chart history → |
| 27 | Take You ThereSean Kingston | 31 | Chart history → |
| 28 | Big Girls Don't CryFergie | 20 | Chart history → |
| 29 | Like You'll Never See Me AgainAlicia Keys | 46 | Chart history → |
| 30 | Who KnewP!nk | 30 | Chart history → |
| 31 | I Don't Wanna Be In Love (Dance Floor Anthem)Good Charlotte | 26 | Chart history → |
| 32 | Sweetest Girl (Dollar Bill)Wyclef Jean Featuring Akon, Lil Wayne & Niia | 37 | Chart history → |
| 33 | Wake Up CallMaroon 5 | 29 | Chart history → |
| 34 | Soulja GirlSoulja Boy Tell'em Featuring I-15 | 32 | Chart history → |
| 35 | Ayo Technology50 Cent Featuring Justin Timberlake & Timbaland | 27 | Chart history → |
| 36 | So SmallCarrie Underwood | 28 | Chart history → |
| 37 | Into The NightSantana Featuring Chad Kroeger | 39 | Chart history → |
| 38 | StaySugarland | 40 | Chart history → |
| 39 | Don't BlinkKenny Chesney | 38 | Chart history → |
| 40 | Misery BusinessParamore | 43 | Chart history → |
| 41 | Shoulda Let You GoKeyshia Cole Introducing Amina | 45 | Chart history → |
| 42 | Baby Don't GoFabolous Featuring Jermaine Dupri | 35 | Chart history → |
| 43 | RockstarNickelback | 34 | Chart history → |
| 44 | Teardrops On My GuitarTaylor Swift | — | Chart history → |
| 45 | My Drink N' My 2 StepCassidy Featuring Swizz Beatz | 41 | Chart history → |
| 46 | GirlfriendBow Wow & Omarion | 56 | Chart history → |
| 47 | Piece Of MeBritney Spears | 63 | Chart history → |
| 48 | Get Buck In HereDJ Felli Fel Featuring Diddy, Akon, Ludacris & Lil Jon | 48 | Chart history → |
| 49 | How 'Bout Them CowgirlsGeorge Strait | 50 | Chart history → |
| 50 | Shadow Of The DayLinkin Park | 54 | Chart history → |
| 51 | FirecrackerJosh Turner | 51 | Chart history → |
| 52 | Gimme MoreBritney Spears | 42 | Listen & explore → |
| 53 | SuffocateJ. Holiday | 72 | Chart history → |
| 54 | Ready, Set, Don't GoBilly Ray Cyrus With Miley Cyrus | 58 | Chart history → |
| 55 | FallClay Walker | 55 | Chart history → |
| 56 | More Than A MemoryGarth Brooks | 53 | Chart history → |
| 57 | Flashing LightsKanye West Featuring Dwele | 75 | Listen & explore → |
| 58 | Livin' Our Love SongJason Michael Carroll | 52 | Chart history → |
| 59 | The PretenderFoo Fighters | 60 | Chart history → |
| 60 | What Do Ya Think About ThatMontgomery Gentry | 65 | Chart history → |
| 61 | Winner At A Losing GameRascal Flatts | 70 | Chart history → |
| 62 | Fake ItSeether | 67 | Chart history → |
| 63 | Roc Boys (And The Winner Is)...JAY-Z | 64 | Chart history → |
| 64 | Pop BottlesBirdman Featuring Lil Wayne | 73 | Chart history → |
| 65 | Free And Easy (Down The Road I Go)Dierks Bentley | 61 | Chart history → |
| 66 | Hood FiggaGorilla Zoe | 59 | Chart history → |
| 67 | EverybodyKeith Urban | 71 | Chart history → |
| 68 | Taking ChancesCeline Dion | 68 | Chart history → |
| 69 | As IfSara Evans | 69 | Chart history → |
| 70 | Letter To MeBrad Paisley | 85 | Chart history → |
| 71 | Freaky GurlGucci Mane | 62 | Chart history → |
| 72 | With YouChris Brown | — | Chart history → |
| 73 | Take Me ThereRascal Flatts | 66 | Chart history → |
| 74 | Watching AirplanesGary Allan | 80 | Chart history → |
| 75 | MistletoeColbie Caillat | 86 | Chart history → |
| 76 | Sensual SeductionSnoop Dogg | — | Chart history → |
| 77 | Nothin' Better To DoLeAnn Rimes | 79 | Chart history → |
| 78 | S.O.S.Jonas Brothers | 57 | Chart history → |
| 79 | Never Too LateThree Days Grace | 77 | Chart history → |
| 80 | This ChristmasChris Brown | 89 | Chart history → |
| 81 | Me EnamoraJuanes | 82 | Chart history → |
| 82 | Pictures Of YouThe Last Goodnight | 81 | Chart history → |
| 83 | Bleed It OutLinkin Park | 83 | Chart history → |
| 84 | OnlineBrad Paisley | 76 | Chart history → |
| 85 | SayJohn Mayer | — | Chart history → |
| 86 | Calabria 2008Enur Featuring Natasja | 90 | Chart history → |
| 87 | IndependentWebbie Featuring Lil' Phat & Lil' Boosie | 99 | Chart history → |
| 88 | Don't Stop The MusicRihanna | 94 | Listen & explore → |
| 89 | If You're Reading ThisTim McGraw | 84 | Chart history → |
| 90 | Stealing CinderellaChuck Wicks | 98 | Chart history → |
| 91 | Work ThatMary J. Blige | — | Chart history → |
| 92 | Go GirlPitbull Featuring Trina & Young Bo$$ | — | Chart history → |
| 93 | Love SongSara Bareilles | 91 | Chart history → |
| 94 | Cleaning This Gun (Come On In Boy)Rodney Atkins | 100 | Chart history → |
| 95 | Still Will50 Cent Featuring Akon | — | Chart history → |
| 96 | I'm Like A Lawyer...(Me & You)Fall Out Boy | 74 | Chart history → |
| 97 | Crying Out For MeMario | — | Chart history → |
| 98 | Sexy MovimientoWisin & Yandel | — | Chart history → |
| 99 | International HarvesterCraig Morgan | — | Chart history → |
| 100 | The Way I AmIngrid Michaelson | — | Chart history → |